Ten Plus Two (+2) Science is a two-year program that provides a solid foundation in science subjects such as physics, chemistry, biology, and mathematics. Through theoretical and practical knowledge, the program aims to develop students' analytical and problem-solving skills. Pursuing a +2 in Science is appropriate for students who want to start or advance their careers in the fields of science, technology, and related disciplines.Graduates of the program can pursue higher education in Science-related fields such as Engineering, Medicine, Agriculture, and Forestry. They can also work in various industries such as Pharmaceuticals, Biotechnology, and Research.

Students interested in enrolling in the Grade 11 Science Subject Group (Physics, Chemistry, Biology/Mathematics/Computer Science/Agriculture) must have the following SEE scores: GPA: 2.0, C+ in Science, and Math and D+ English, Nepali and Social Studies

Which is the best science college for a plus two education? There are thousands of colleges located both inside and outside the Kathmandu Valley that offer 10 Plus 2 (+2) in Science. This curiosity is shared by students who have excelled academically in SEE. Students looking for the best science college are those who want to pursue medical (MBBS, BDS, Pharmacy, Nursing, etc.) courses after finishing class 11 and 12 in science faculty or those who want to pursue engineering, CA, etc. Kendrabindu, a leading online news portal, has published a list of the Top 10 Plus 2 (+2) Science Colleges located both inside and outside Kathmandu Valley, as well as the Top 20 Plus 2 Colleges, and Top +2 Management Colleges in Nepal for the year 2080 (2022/ 2023) based on various parameters for the rankings. The Top +2 Colleges in Science Stream were shortlisted and selected based on the number of students who received full scholarships in Engineering and Medical courses during their higher education.

The following are some of the best 10 Plus 2 (+2) Science Colleges in Kathmandu Valley for 2022/ 2023 (2080).

Capital College and Research Centre (CCRC)
Capital College and Research Centre (CCRC), located at Koteshwor (Near Balkumari Bridge), Kathmandu,  is one the leading educational institution in the nation for the +2 level of education.
- Address: Koteshwor (Near Balkumari Bridge), Kathmandu
- Program: Science, Management, Law
- Phone: 5100423, 5100456
- Web: https://ccrc.edu.np/

Kathmandu Model Secondary School (KMC)
Kathmandu Model College (KMC) has carved out an enviable position at the top of the country's premier +2 colleges.

- Address: Bagbazar, Kathmandu
- Phone: 01-5342121, 5358915
- Total area: 16 Ropani
- Programs: Science, Management, Law
- Web: www.ktmmodelcollege.edu.np

- Address: Balkumari, Lalitpur
- Programs: Science, Management, Law
- Phone: 01-5201331, 5201334
- Web: https://kmclalitpur.edu.np

St. Xavier's
ST. XAVIER’S COLLEGE, Kathmandu, is an educational institution of higher learning established and managed by the Nepal Jesuit Society. The Jesuits began their educational work in Nepal in 1951 with the opening of St. Xavier’s School, Godavari, followed by St. Xavier’s School, Jawalakhel, St. Xavier’s School, Deonia, Moran Memorial School, Maheshpur,and St. Xavier’s School, Sadakbari.
- Address: Maitighar, Kathmandu Nepal
- Program: Science
- Phone: +977-01-5321365, 5344636
- Web: https://www.sxc.edu.np/

Trinity International College
Trinity stands for academic accomplishment. The College has a congenial environment, state-of-the-art infrastructure, and reputed faculty. Managed by a devoted team of professionals advised by outstanding national and foreign advisors, the institution ensures student requirement and academic support go hand in hand.
- Address: Dillibazar Height, Kathmandu
- Program: Science, Management, Humanities
- Phone: +977-1-4445955, 4445956
- Web: https://www.trinity.edu.np/

Prasadi Academy
Prasadi Academy has maintained a competitive position among Nepal's prestigious +2 groups since its inception in 1997, thanks to its commitment to the highest educational standards. It fosters students' critical thinking and moral sensitivity through its curriculum, +2 life, and extracurricular activities.
- Address: Manbhawan, Lalitpur
- Programs: Science, Management
- Phone no: 5541117, 5530562
- Web: www.prasadi.edu.np

Pinnacle Academy
Situated in the heart of Lalitpur, Pinnacle Academy SS/College is a global standard academic institution imparting quality education to her students by imbuing them with the feelings of sincerity. humanity and patriotism.
- Address: Lagankhel, Lalitpur
- Program: Science, Management, Law and Humanities
- Phone: 01-5544023,01-5544024,01-5540882
- Web: https://www.pinnacleacademy.edu.np/

Xavier International College
Xavier International College believes in fostering an environment that encourages students to develop their skills, knowledge, and creativity to the fullest. The college strives to provide a world-class education to its students by offering a rigorous curriculum, outstanding faculty, and state-of-the-art facilities.

- Address: Kalopul, Kathmandu
- Program: Science, Management
- Phone: 01-4439472, 01-4539492
- webL : https://www.xavier.edu.np

National School of Sciences
NIST National School of Sciences is a premier education institution, which was established in 1993. It is situated at Lainchour, strategically important location in the Kathmandu valley, and is one of the constituent institutions under the NIST Foundation. The school has been conducting Plus 2 programme (Grade 11 – 12), now Upper Secondary school classes, both in Science, Humanities and Management for the last three decades.

- Address: Lainchour, Kathmandu
- Program: Management, Law, Humanities
- Phone: 01-4522050, +977-01-5104450, 5104529
- Web: www.nist.edu.np

St. Lawrence College
St. Lawrence Secondary School is one of the leading academic institutions in Nepal, was established in 1997 AD. It is recognized for its friendly, caring, disciplined and excellent academic environment. We focus to stretch the admirable learning atmosphere to all the students to support them to develop the best that is embryonic in children, to prepare them for the upcoming challenges.
 
- Address: Chabahil, pipalbot, Kathmandu, Nepal
- Program: Science, Management, Law and Humanities
- Phone: 01-4587864
- Web: https://www.stlawrence.edu.np

Sainik Awasiya Mahavidyalaya
Guided by the divine motto “Gyanena Paramo Sewa” (Imparting Knowledge Is the Greatest Service) in letter and spirit, Sainik Awasiya Mahavidyalaya, Bhaktapur (SAMB) is running under the aegis of Nepali  Army Welfare Fund. SAMB has a glorious history dating back to 2035 B.S.

- Address: Sallaghari, Bhaktapur, Nepal
- Program: Scieeence, Management, Humanities
- Phone: 01-6610051
- Web: www.bsamv.edu.np

Khwopa Higher Secondary School
KSS was founded by Bhakapur Municipality on 16th Shrawan, 2056 (1st August, 1999). Buoyed up with the idea of enlightening the whole society and the nation by means of providing quality education, the municipality made an aggressive initiation realizing their long term vision of the over all development of Bhaktapur.

- Address: Dekocha,Bhaktapur, Bhaktapur, Nepal
- Program: Science, Management, Law, Humanities
- Phone: 01-6614336
- Web: https://www.khwopahss.edu.np

St. Xavier's College
ST. XAVIER’S COLLEGE, Kathmandu, is an educational institution of higher learning established and managed by the Nepal Jesuit Society. The Jesuits began their educational work in Nepal in 1951 with the opening of St. Xavier’s School, Godavari, followed by St. Xavier’s School, Jawalakhel, St. Xavier’s School, Deonia, Moran Memorial School, Maheshpur,and St. Xavier’s School, Sadakbari.

- Address: Maitighar, Kathmandu Nepal
- Program: Science
- Phone: +977-01-5321365, 5344636
- Web: https://www.sxc.edu.np

 VS Niketan School
V.S Niketan Education Foundation –  Established by academician late Dr. B.R. Pokharel in 2038. VSN has been awarded as the best school of the nation with the nation shield and flag for the year 2065. Its graduates occupy admirable positions in medi­cine, engineering, banking and administration in Nepal as well as in abroad.

- Address: Minbhawan Kathmandu
- Program: Science, Management
- Phone: +977-1-4111899, +977-1-4111602, +977-1-4106576
- Web: https://www.vsniketan.edu.np

Reliance International Academy
Reliance Int'l Academy, established by a team of highly qualified and dedicated academicians and professionals, is a student-friendly institution providing quality educational services since 2050 B.S. Reliance International has the distinction of being awarded by the NEB Board for its excellent results in Grades XI and XII.

- Address: Kapan-10, Budanilkantha, Kathmandu, Nepal
- Program: Science, Management, Humanities and Law
- Phone: 01-4811552
- Web: https://www.rianepal.edu.np

Top +2 Sciences Colleges in Nepal ( outside Valley) are as follows:

Arniko College
- Address: Tintolia, Biratnagar-13, Morang
- Program: Management
- Phone: 021-470149
- Web: https://www.arnikohm.edu.np

Shikshadeep College
Shikshadeep, one of the best colleges of Nepal and the leading college of Province No.1. Shikshadeep has been continuously proving its excellence and quality education through outstanding result and turning the aspiration of the students into reality since the very year of its establishment.

- Address: Main Road, Neel Sadan, Biratnagar, Nepal
- Program: Science, Management
- Phone: 021-450397
- Web: https://www.shikshadeep.edu.np

New Hoirzon
It started its academic journey in 2046 B.S. (1989AD) in the name of New Horizon with unparalleled commitment to academic excellence, under the efficient management of time and devoted academicians, social workers' philanthropist, business community, professors and lecturers, professional teachers, eminent sport- personalities and most responsible local residents.

- Address: Butwal, Nepal
- Program: Management, Science
- Phone: 071-437602
- Web: https://newhorizon.edu.np
 
Sagarmatha Higher Secondary School
Sagarmatha Higher Secondary School is one of the leading educational institutions run by academicians who have been nurturing young minds for more than three decades.

- Address: Nayabazar, Pokhara-9, Nepal
- Program: Science, Management
- Phone: 061-532798, 533507
- Web: https://sagarmathapokhara.edu.np